From the methodological point of view, the project will develop novel 1H- and 19F-NMR methods for the characterization of protein-ligand interactions. Specifically, we will develop an NMR based method to screen libraries of compounds that selectively associate to a predefined binding site. From the applied point of view, the project will try to obtain novel modulators of the heme biosynthetic pathway, specifically targeting ALAS2, the rate limiting enzyme in the pathway. This approach may provide new therapeutic intervention lines to several rare diseases of the porphyria family.
Information about the related PhD position and how to apply are available here.
