Description of position DC02
Title of the project
Peptide-based receptors
Description of the project
With the aim of creating robust, potent and
selective carbohydrate binding molecules (CBMs) whose synthesis can be scaled
up, peptides or small proteins are attractive.
Their specific fold, presence of amino acids capable of polar hydrogen
bonds and CH-p interactions,
have the potential to achieve the goals.
Designs inspired by nature will be approached via peptide synthesis and
mini-protein expression. Studying their
fold and designing multivalent versions, is part of the goals towards highly
potent and practical CBMs. Molecular modeling, advanced NMR and state of the
art peptide synthesis and protein expression are the key techniques. Application area’s include the interference
with adhesion and infection with bacteria and viruses.
Research Field
Main area: Organic and peptide chemistry
Specific area: biochemistry
Work location
Utrecht University (ww.uu.nl), Department of Chemical Biology and Drug Discovery (https://www.uu.nl/en/research/chemical-biology-and-drug-discovery), Adress: Universiteitsweg 99,
3584 CG Utrecht, The Netherlands
Supervisor
prof. Roland Pieters (r.j.pieters@uu.nl)
Required educational level
Master in organic chemistry, chemical biology, drug discovery, analytical chemistry, supramolecular chemistry or related
Skills or qualitfication required
Organic synthesis, carbohydrate synthesis, spectroscopy, binding studies
Additional Benefit
We offer:
- a position for four years;
- a gross monthly salary ranging from €2,770 in the first year and increasing to €3,539 in the fourth year in the case of full-time employment (salary scale P under the Collective Labour Agreement for Dutch Universities (CAO NU);
- 8% holiday pay and 8.3% year-end bonus;
- a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU.
In addition to the terms of employment external link laid down in the CAO NU, Utrecht University has a number of schemes and facilities of its own for employees. This includes schemes facilitating professional development external link, leave schemes and schemes for sports and cultural activities external link, as well as discounts on software and other IT products. We also offer access to additional employee benefits through our Terms of Employment Options Model. In this way, we encourage our employees to continue to invest in their growth. For more information, please visit Working at Utrecht University (https://www.uu.nl/en/organisation/working-at-utrecht-university)
Tentative starting date of the contract
01/09/2024
Eligibility Criteria
Eligibility criteria available here.
