Description of position DC04
Title of the project
Development of saccharide analogues for protein functionalization and as ligands for binding studies with carbohydrate binding molecules (CBMs). Multivalent presentation of CBMs.
Description of the project
The project, in collaboration with Prof. Cristina Nativi, aims to synthesise glycosidic analogues of biologically relevant carbohydrates for their conjugation with proteins and materials for molecular recognition studies with synthetic receptors. The group has extensive experience in carbohydrate chemistry for the development of glycomimetics and saccharide analogues for the tuning of glycan-protein recognition events. This project also aims to conjugate synthetic receptors to obtain functional materials to study the role of multivalent presentation in carbohydrate recognition and separation.
Background literature:
Niosomes Functionalized with a Synthetic Carbohydrate Binding Agent for Mannose-Targeted Doxorubicin Delivery. Pharmaceutics, 2023, 15 (1), art. no. 235.
Towards Biomimetic Recognition of Glycans by Synthetic Receptors. ChemPlusChem 2023, e202300598
Biomimetic Tweezers for N-Glycans: Selective Recognition of the Core GlcNAc2 Disaccharide of the Sialylglycopeptide SGP Chem. Eur. J., 2023, 29 (18), art. no. e202203591.
Research Field
Main area: Chemistry
Specific area: Organic Chemistry, Carbohydrate Chemistry
Work location
Università degli Studi di Firenze, Department of Chemistry “Ugo Schiff”, DICUS,
Via della Lastruccia 3-13, I-50019, Sesto Fiorentino, Firenze (ITALY).
Institute websites:
Università degli Studi di Firenze: https://www.unifi.it/
Department of Chemistry “Ugo Schiff”, DICUS: https://www.chim.unifi.it/
Research group website: https://sites.google.com/unifi.it/glycomore/home-page
Supervisor
prof. Cristina Nativi (cristina.nativi@unifi.it)
Required educational level
Master’s degree or equivalent, preferably in Chemistry, Medicinal Chemistry, or similar.
Tentative starting date of the contract
01/11/2024
Eligibility Criteria
Eligibility criteria available here.
